TY - JOUR T1 - Nasal expression of SARS-CoV-2 entry receptors in newborns JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - 95 LP - 97 DO - 10.1136/archdischild-2020-321334 VL - 107 IS - 1 AU - Santtu Heinonen AU - Otto Helve AU - Sture Andersson AU - Cecilia Janér AU - Liina Süvari AU - Anu Kaskinen Y1 - 2022/01/01 UR - http://fn.bmj.com/content/107/1/95.abstract N2 - Background SARS-CoV-2 infection is typically mild in children. Lower expression of SARS-CoV-2 entry receptors in the nasal epithelia have been described in children compared with adults. However, data from newborns are lacking. We compared nasal expression of four SARS-CoV-2 entry receptors between term and preterm newborns and adults.Methods Nasal scrape samples were obtained from 28 newborns (17 term and 11 preterm) and 10 adults. Reverse-transcription quantitative PCR was used to measure mRNA expression of ACE2, transmembrane serine protease 2 (TMPRSS2), neuropilin 1 (NRP1) and neuropilin 2 (NRP2) and insulin-like growth factor 1 receptor (IGF1R).Results Expression levels of ACE2, TMPRSS2, NRP1 and NRP2 were lower in term and preterm newborns and IGF1R lower in term newborns compared with adults (p<0.05).Conclusions Both term and preterm newborns, compared with adults, have lower expression of SARS-CoV-2 entry receptors in nasal epithelium.Data are available on reasonable request. Data collected for this study may be shared with other investigators after approval of methodologically sound proposal. Proposals should be directed to corresponding author. To gain access, data requestors will need to sign a data access agreement. ER -