TY - JOUR T1 - Impact of the new NICE guidance 2021 on management of early onset neonatal sepsis JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed DO - 10.1136/archdischild-2021-322822 SP - fetalneonatal-2021-322822 AU - Laura Macaskill AU - Samantha Slee AU - Tim J van Hasselt AU - Muhammed Naseem AU - Andrew K Ewer AU - Pinki Surana A2 - , Y1 - 2021/09/11 UR - http://fn.bmj.com/content/early/2021/10/19/archdischild-2021-322822.abstract N2 - In April 2021, the National Institute for Health and Care Excellence (NICE) published new guidelines for neonatal infection,1 replacing the 2012 guidance. In order to reduce antibiotic usage in healthy infants, NICE modified risk factors and allowed use of Kaiser Permanente Sepsis Risk Calculator (KP-SRC)2 as an alternative with prospective audit. KP-SRC provides recommendations for antibiotics, culture with observation or observation only. Previous studies,3 including from our group,4 demonstrated significant reductions (up to 84%) in antibiotic usage on virtual application of KP-SRC compared with NICE 2012. No studies examining the impact of NICE 2021, or its effect in conjunction with KP-SRC, have yet been published.We performed a retrospective application of NICE 2021 using data collected from 11 neonatal units (NNUs) in the West Midlands, UK. We included all infants born ≥34 weeks’ gestation between 1 January 2020 and 29 February 2020, not directly admitted to NNU, started on antibiotics following NICE 2012 guidelines. KP-SRC was also retrospectively applied (early-onset Sepsis (EOS) incidence rate 2/1000; regional … ER -