TY - JOUR T1 - Hypotension in Preterm Infants (HIP) randomised trial JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - 398 LP - 403 DO - 10.1136/archdischild-2020-320241 VL - 106 IS - 4 AU - Eugene M Dempsey AU - Keith J Barrington AU - Neil Marlow AU - Colm Patrick Finbarr O'Donnell AU - Jan Miletin AU - Gunnar Naulaers AU - Po-Yin Cheung AU - John David Corcoran AU - Afif Faisal EL-Khuffash AU - Geraldine B Boylan AU - Vicki Livingstone AU - Gerard Pons AU - Jozef Macko AU - David Van Laere AU - Hana Wiedermannova AU - Zbyněk Straňák A2 - , Y1 - 2021/07/01 UR - http://fn.bmj.com/content/106/4/398.abstract N2 - Objective To determine whether restricting the use of inotrope after diagnosis of low blood pressure (BP) in the first 72 hours of life affects survival without significant brain injury at 36 weeks of postmenstrual age (PMA) in infants born before 28 weeks of gestation.Design Double-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.Setting 10 sites across Europe and Canada.Participants Infants born before 28 weeks of gestation were eligible if they had an invasive mean BP less than their gestational age that persisted for ≥15 min in the first 72 hours of life and a cerebral ultrasound free of significant (≥ grade 3) intraventricular haemorrhage.Intervention Participants were randomly assigned to saline bolus followed by either a dopamine infusion (standard management) or placebo (5% dextrose) infusion (restrictive management).Primary outcome Survival to 36 weeks of PMA without severe brain injury.Results The trial terminated early due to significant enrolment issues (7.7% of planned recruitment). 58 infants were enrolled between February 2015 and September 2017. The two groups were well matched for baseline variables. In the standard group, 18/29 (62%) achieved the primary outcome compared with 20/29 (69%) in the restrictive group (p=0.58). Additional treatments for low BP were used less frequently in the standard arm (11/29 (38%) vs 19/29 (66%), p=0.038).Conclusion Though this study lacked power, we did not detect major differences in clinical outcomes between standard or restrictive approach to treatment. These results will inform future studies in this area.Trial registration number NCT01482559, EudraCT 2010-023988-17.Data may be obtained from a third party and are not publicly available. It is currently not possible to share the HIP Trial data set. ER -