RT Journal Article
SR Electronic
T1 Changes over time in quality of life of school-aged children born extremely preterm: 1991–2005
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 425
OP 429
DO 10.1136/archdischild-2020-320582
VO 106
IS 4
A1 Stacey Peart
A1 Jeanie Ling Yoong Cheong
A1 Gehan Roberts
A1 Noni Davis
A1 Peter J Anderson
A1 Lex W Doyle
A1 ,
YR 2021
UL http://fn.bmj.com/content/106/4/425.abstract
AB Objective To compare health-related quality of life (HRQOL) at 8 years in children born extremely preterm (EP) with contemporaneous term-born controls over three epochs: 1991–92, 1997 and 2005.Design Prospective recruitment of geographic cohorts across three distinct eras. Utilities were calculated from the parent-completed Health Utilities Index (HUI), version 2 (1991–92 and 1997 cohorts) and version 3 (2005 cohort). Differences in utilities >0.05 are clinically important.Setting The state of Victoria, Australia.Patients 475 EP (<28 weeks’ gestation) and 570 term controls.Main outcome measures Utilities of children born EP compared with term controls within each era, and paired differences between an EP and matched controls compared across eras.Results Overall, 86% of survivors had utility data at 8 years of age; 475 EP and 570 controls. In all eras, parent-reported utilities were lower for children born EP compared with controls (difference in medians (95% CIs); 1991–92, −0.053 (–0.071 to –0.035); 1997, –0.053 (−0.072 to –0.034); 2005, –0.082 (−0.097 to –0.068)). Mean differences (MD) between EP children and matched controls within each era were lower in the 2005 cohort compared with both the 1991–92 cohort (MD −0.054, 95% CI −0.097 to –0.010) and the 1997 cohort (MD −0.053, 95% CI −0.097 to –0.009).Conclusion Children born EP in the postsurfactant era have clinically important reductions in parent-reported HRQOL compared with controls, which may be worsening over time.All data relevant to the study are included in the article or uploaded as supplementary information. Deidentified individual participant data will not be made available.