PT - JOURNAL ARTICLE AU - Bordessoule, Alice AU - Moreira, Amelia AU - Felice Civitillo, Cristina AU - Combescure, Christophe AU - Polito, Angelo AU - Rimensberger, Peter C TI - Comparison of inspiratory effort with three variable-flow nasal continuous positive airway pressure devices in preterm infants: a cross-over study AID - 10.1136/archdischild-2020-320531 DP - 2021 Jul 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - 404--407 VI - 106 IP - 4 4099 - http://fn.bmj.com/content/106/4/404.short 4100 - http://fn.bmj.com/content/106/4/404.full SO - Arch Dis Child Fetal Neonatal Ed2021 Jul 01; 106 AB - Objective Patient’s work of breathing may vary between different neonatal nasal continuous positive airway pressure (NCPAP) devices. Therefore, we aimed to compare the inspiratory effort of three variable-flow NCPAP delivery systems used in preterm infants.Design Cross-over study.Patients/setting From June 2015 to August 2016, 20 preterm infants weighing ≤2500 g requiring NCPAP for mild respiratory distress syndrome were enrolled.Interventions Each patient was successively supported by three randomly assigned variable-flow NCPAP systems (MedinCNO, Infant Flow and Servo-i) for 20 min while maintaining the same continuous positive airway pressure level as the patient was on before the study period.Main outcome measures Patients’ inspiratory effort was estimated by calculating the sum of the difference between maximal inspiratory and baseline electrical activity of the diaphragm (∆EAdi) for 30 consecutive breaths, and after normalising this obtained value for the timing of the 30 breaths.Results Physiological parameters (oxygen saturation measured by pulse oximetry, respiratory rate, heart beat, transcutaneous partial pressure CO2) and oxygen requirements remained identical between the three NCPAP systems. Although a wide variability in inspiratory effort could be observed, there were no statistically significant differences between the three systems for the sum of ∆EAdi for 30 breaths: CNO, 262 (±119) µV; IF, 352 (±262) µV; and SERVO-i, 286 (±126) µV, and the ∆EAdi reported on the timing of 30 breaths (sum ∆EAdi/s): CNO, 6.1 (±2.3) µV/s; IF, 7.9 (±4.9) µV/s; SERVO-i, 7.6 (±3.6) µV/s.Conclusion In a neonatal population of preterm infants, inspiratory effort is comparable between the three tested modern variable-flow NCPAP devices.Data are available upon reasonable request.