@article {Moralesfetalneonatal-2020-321164, author = {Maria Moreno Morales and Paolo Montaldo and Phoebe Ivain and Stuti Pant and Vijay Kumar and Vaisakh Krishnan and Seetha Shankaran and Sudhin Thayyil}, title = {Association of Total Sarnat Score with brain injury and neurodevelopmental outcomes after neonatal encephalopathy}, elocation-id = {fetalneonatal-2020-321164}, year = {2021}, doi = {10.1136/archdischild-2020-321164}, publisher = {BMJ Publishing Group}, abstract = {We examined the association of Total Sarnat Score (TSS) with brain injury on neonatal magnetic resonance (MR) and adverse neurodevelopmental outcome (NDO) (death or moderate or severe disability) at 2 years of age in 145 infants undergoing therapeutic hypothermia for neonatal encephalopathy. TSS was associated with basal ganglia/thalamic injury on conventional MR (p=0.03) and thalamic N-acetyl aspartate on MR spectroscopy (R2=0.16, p=0.004) at 2 weeks of age, and Bayley Composite Cognitive (R2=0.18, p=0.01), Motor (R2=0.15, p=0.02) and Language (R2=0.11, p=0.01) Scores at 2 years of age after adjustment for seizures at the time of neurological assessment. The accuracy of TSS (area under the curve (AUC)=0.71) for predicting adverse NDO was similar to the modified Sarnat staging (AUC=0.72). TSS of \>12 within 6 hours of birth indicated high risk of adverse NDO, while TSS of \<4 indicated intact survival and was reassuring of a good outcome among cooled infants.Data are available upon reasonable request and once all the different substudies have been published. The data that support the findings of this study are available from the corresponding author, upon reasonable request.}, issn = {1359-2998}, URL = {https://fn.bmj.com/content/early/2021/05/05/archdischild-2020-321164}, eprint = {https://fn.bmj.com/content/early/2021/05/05/archdischild-2020-321164.full.pdf}, journal = {Archives of Disease in Childhood - Fetal and Neonatal Edition} }