RT Journal Article SR Electronic T1 Hypotension in Preterm Infants (HIP) randomised trial JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP fetalneonatal-2020-320241 DO 10.1136/archdischild-2020-320241 A1 Eugene M Dempsey A1 Keith J Barrington A1 Neil Marlow A1 Colm Patrick Finbarr O'Donnell A1 Jan Miletin A1 Gunnar Naulaers A1 Po-Yin Cheung A1 John David Corcoran A1 Afif Faisal EL-Khuffash A1 Geraldine B Boylan A1 Vicki Livingstone A1 Gerard Pons A1 Jozef Macko A1 David Van Laere A1 Hana Wiedermannova A1 Zbyněk Straňák A1 , YR 2021 UL http://fn.bmj.com/content/early/2021/02/24/archdischild-2020-320241.abstract AB Objective To determine whether restricting the use of inotrope after diagnosis of low blood pressure (BP) in the first 72 hours of life affects survival without significant brain injury at 36 weeks of postmenstrual age (PMA) in infants born before 28 weeks of gestation.Design Double-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.Setting 10 sites across Europe and Canada.Participants Infants born before 28 weeks of gestation were eligible if they had an invasive mean BP less than their gestational age that persisted for ≥15 min in the first 72 hours of life and a cerebral ultrasound free of significant (≥ grade 3) intraventricular haemorrhage.Intervention Participants were randomly assigned to saline bolus followed by either a dopamine infusion (standard management) or placebo (5% dextrose) infusion (restrictive management).Primary outcome Survival to 36 weeks of PMA without severe brain injury.Results The trial terminated early due to significant enrolment issues (7.7% of planned recruitment). 58 infants were enrolled between February 2015 and September 2017. The two groups were well matched for baseline variables. In the standard group, 18/29 (62%) achieved the primary outcome compared with 20/29 (69%) in the restrictive group (p=0.58). Additional treatments for low BP were used less frequently in the standard arm (11/29 (38%) vs 19/29 (66%), p=0.038).Conclusion Though this study lacked power, we did not detect major differences in clinical outcomes between standard or restrictive approach to treatment. These results will inform future studies in this area.Trial registration number NCT01482559, EudraCT 2010-023988-17.