@article {Brucknerfetalneonatal-2020-319473, author = {Marlies Bruckner and Megan O{\textquoteright}Reilly and Tze-Fun Lee and Mattias Neset and Po-Yin Cheung and Georg M Schm{\"o}lzer}, title = {Effects of varying chest compression depths on carotid blood flow and blood pressure in asphyxiated piglets}, elocation-id = {fetalneonatal-2020-319473}, year = {2021}, doi = {10.1136/archdischild-2020-319473}, publisher = {BMJ Publishing Group}, abstract = {Background Current neonatal resuscitation guidelines recommend chest compressions (CCs) should be delivered to a depth of approximately 1/3 of the anterior{\textendash}posterior (AP) chest diameter. The aim of the study was to investigate the haemodynamic effects of different CC depths in a neonatal piglet model.Methods CCs were performed with an automated CC machine with 33\%, 40\% and 25\% AP chest diameter in all piglets in the same order for a duration of 3 min each.Results Eight newborn piglets (age 1{\textendash}3 days, weight 1.7{\textendash}2.3 kg) were included in the study. Carotid blood flow (CBF) and systolic blood pressure were the highest using a CC depth of 40\% AP chest diameter (19.3{\textpm}7.5 mL/min/kg and 58{\textpm}32 mm Hg).Conclusion CC depth influences haemodynamic parameters in asphyxiated newborn piglets during cardiopulmonary resuscitation. The highest CBF and systolic blood pressure were achieved using a CC depth of 40\% AP chest diameter.Trial registration number PCTE0000148.}, issn = {1359-2998}, URL = {https://fn.bmj.com/content/early/2021/02/03/archdischild-2020-319473}, eprint = {https://fn.bmj.com/content/early/2021/02/03/archdischild-2020-319473.full.pdf}, journal = {Archives of Disease in Childhood - Fetal and Neonatal Edition} }