PT - JOURNAL ARTICLE AU - Sanne Arjaans AU - Meindina G Haarman AU - Marcus T R Roofthooft AU - Marian W F Fries AU - Elisabeth M W Kooi AU - Arend F Bos AU - Rolf M F Berger TI - Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age AID - 10.1136/archdischild-2019-318531 DP - 2021 Jan 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - 45--50 VI - 106 IP - 1 4099 - http://fn.bmj.com/content/106/1/45.short 4100 - http://fn.bmj.com/content/106/1/45.full SO - Arch Dis Child Fetal Neonatal Ed2021 Jan 01; 106 AB - Objective To determine the survival and evolution of pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD) in extremely premature born infants beyond 36 weeks postmenstrual age (PMA).Design A single-centre retrospective cohort study from a university hospital.Patients Extremely preterm (gestational age <30 weeks and/or birth weight <1000 g) infants, born between 2012 and 2017, in the University Medical Center Groningen with confirmed PH at/beyond 36 weeks PMA.Main outcome measures Survival, mortality rate and PH resolution. Patient characteristics, treatment, presence and evolution of PH were collected from patient charts.Results Twenty-eight infants were included. All had BPD, while 23 (82%) had severe BPD and 11 infants (39%) died. Survival rates at 1, 3 and 7 months from 36 weeks PMA were 89%, 70% and 58%, respectively. In 16 of the 17 surviving infants, PH resolved over time, with a resolution rate at 1 and 2 years corrected age of 47% and 79%, respectively. At 2.5 years corrected age, the resolution rate was 94%.Conclusions These extremely preterm born infants with PH-BPD had a survival rate of 58% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.