@article {Arjaans45, author = {Sanne Arjaans and Meindina G Haarman and Marcus T R Roofthooft and Marian W F Fries and Elisabeth M W Kooi and Arend F Bos and Rolf M F Berger}, title = {Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age}, volume = {106}, number = {1}, pages = {45--50}, year = {2021}, doi = {10.1136/archdischild-2019-318531}, publisher = {BMJ Publishing Group}, abstract = {Objective To determine the survival and evolution of pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD) in extremely premature born infants beyond 36 weeks postmenstrual age (PMA).Design A single-centre retrospective cohort study from a university hospital.Patients Extremely preterm (gestational age \<30 weeks and/or birth weight \<1000 g) infants, born between 2012 and 2017, in the University Medical Center Groningen with confirmed PH at/beyond 36 weeks PMA.Main outcome measures Survival, mortality rate and PH resolution. Patient characteristics, treatment, presence and evolution of PH were collected from patient charts.Results Twenty-eight infants were included. All had BPD, while 23 (82\%) had severe BPD and 11 infants (39\%) died. Survival rates at 1, 3 and 7 months from 36 weeks PMA were 89\%, 70\% and 58\%, respectively. In 16 of the 17 surviving infants, PH resolved over time, with a resolution rate at 1 and 2 years corrected age of 47\% and 79\%, respectively. At 2.5 years corrected age, the resolution rate was 94\%.Conclusions These extremely preterm born infants with PH-BPD had a survival rate of 58\% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.}, issn = {1359-2998}, URL = {https://fn.bmj.com/content/106/1/45}, eprint = {https://fn.bmj.com/content/106/1/45.full.pdf}, journal = {Archives of Disease in Childhood - Fetal and Neonatal Edition} }