PT - JOURNAL ARTICLE AU - Rachel Morris AU - Steve Jones AU - Sujoy Banerjee AU - Andrew Collinson AU - Hannah Hagan AU - Hannah Walsh AU - Graham Thornton AU - Ian Barnard AU - Chris Warren AU - Jennifer Reid AU - Alison Busfield AU - Jean Matthes TI - Comparison of the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with NICE guideline CG149 in infants ≥34 weeks’ gestation who developed early-onset sepsis AID - 10.1136/archdischild-2019-317165 DP - 2020 Nov 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - 581--586 VI - 105 IP - 6 4099 - http://fn.bmj.com/content/105/6/581.short 4100 - http://fn.bmj.com/content/105/6/581.full SO - Arch Dis Child Fetal Neonatal Ed2020 Nov 01; 105 AB - Objective To compare the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with National Institute for Health and Care Excellence (NICE) guideline CG149 in infants ≥34 weeks’ gestation who developed early-onset sepsis (EOS).Design Retrospective multicentre study.Setting Five maternity services in South West of England and Wales.Patients 70 infants with EOS (<72 hours) confirmed on blood or cerebrospinal fluid culture.Methods Retrospective virtual application of NICE and SRC through review of maternal and neonatal notes.Main outcome measure The number of infants recommended antibiotics by 4 hours of birth.Results The incidence of EOS ≥34 weeks was 0.5/1000 live births. Within 4 hours of birth, antibiotics were recommended for 39 infants (55.7%) with NICE, compared with 27 (38.6%) with SRC. The 12 infants advised early treatment by NICE but not SRC remained well, only one showing transient mild symptoms after 4 hours. Another four babies received antibiotics by 4 hours outside NICE and SRC guidance. The remaining 27 infants (38.6%) received antibiotics when symptomatic after 4 hours. Only one infant who was unwell from birth, died. Eighty-one per cent of all EOS infants were treated for clinical reasons rather than for risk factors alone.Conclusion While both tools were poor in identifying EOS within 4 hours, NICE was superior to SRC in identifying asymptomatic cases. Currently, four out of five EOS have symptoms at first identification, the majority of whom present within 24 hours of birth. Antibiotic stewardship programmes using SRC should include enhanced observation for infants currently treated within NICE guidance.