TY - JOUR T1 - Economic evaluation alongside the Speed of Increasing milk Feeds Trial (SIFT) JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - 587 LP - 592 DO - 10.1136/archdischild-2019-318346 VL - 105 IS - 6 AU - Warda Tahir AU - Mark Monahan AU - Jon Dorling AU - Oliver Hewer AU - Ursula Bowler AU - Louise Linsell AU - Christopher Partlett AU - Janet Elizabeth Berrington AU - Elaine Boyle AU - Nicolas Embleton AU - Samantha Johnson AU - Alison Leaf AU - Kenny McCormick AU - William McGuire AU - Ben J Stenson AU - Ed Juszczak AU - Tracy E Roberts Y1 - 2020/11/01 UR - http://fn.bmj.com/content/105/6/587.abstract N2 - Objective To evaluate the cost-effectiveness of two rates of enteral feed advancement (18 vs 30 mL/kg/day) in very preterm and very low birth weight infants.Design Within-trial economic evaluation alongside a multicentre, two-arm parallel group, randomised controlled trial (Speed of Increasing milk Feeds Trial).Setting 55 UK neonatal units from May 2013 to June 2015.Patients Infants born <32 weeks’ gestation or <1500 g, receiving less than 30 mL/kg/day of milk at trial enrolment. Infants with a known severe congenital anomaly, no realistic chance of survival, or unlikely to be traceable for follow-up, were ineligible.Interventions When clinicians were ready to start advancing feed volumes, infants were randomised to receive daily increments in feed volume of 30 mL/kg (intervention) or 18 mL/kg (control).Main outcome measure Cost per additional survivor without moderate to severe neurodevelopmental disability at 24 months of age corrected for prematurity.Results Average costs per infant were slightly higher for faster feeds compared with slower feeds (mean difference £267, 95% CI −6928 to 8117). Fewer infants achieved the principal outcome of survival without moderate to severe neurodevelopmental disability at 24 months in the faster feeds arm (802/1224 vs 848/1246). The stochastic cost-effectiveness analysis showed a likelihood of worse outcomes for faster feeds compared with slower feeds.Conclusions The stochastic cost-effectiveness analysis shows faster feeds are broadly equivalent on cost grounds. However, in terms of outcomes at 24 months age (corrected for prematurity), faster feeds are harmful. Faster feeds should not be recommended on either cost or effectiveness grounds to achieve the primary outcome. ER -