PT - JOURNAL ARTICLE AU - Sonja Baldursdottir AU - Markus Falk AU - Snorri Donaldsson AU - Baldvin Jonsson AU - Thomas Drevhammar TI - Basic principles of neonatal bubble CPAP: effects on CPAP delivery and imposed work of breathing when altering the original design AID - 10.1136/archdischild-2019-318073 DP - 2020 Sep 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - 550--554 VI - 105 IP - 5 4099 - http://fn.bmj.com/content/105/5/550.short 4100 - http://fn.bmj.com/content/105/5/550.full SO - Arch Dis Child Fetal Neonatal Ed2020 Sep 01; 105 AB - Background The original bubble continuous positive airway pressure (bCPAP) design has wide-bore tubing and a low-resistance interface. This creates a stable airway pressure that is reflected by the submersion depth of the expiratory tubing. Several systems with alterations to the original bCPAP design are now available. Most of these are aimed for use in low-income and middle-income countries and have not been compared with the original design.Objective We identified three major alterations to the original bCPAP design: (1) resistance of nasal interface, (2) volume of dead space and (3) diameter of expiratory tubing. Our aim was to study the effect of these alterations on CPAP delivery and work of breathing in a mechanical lung model. Dead space should always be avoided and was not further tested.Methods The effect of nasal interface resistance and expiratory tubing diameter was evaluated with simulated breathing in a mechanical lung model without interface leakage. The main outcome was delivered CPAP and imposed work of breathing.Results High-resistance interfaces and narrow expiratory tubing increased the work of breathing. Additionally, narrow expiratory tubing resulted in higher CPAP levels than indicated by the submersion depth.Conclusion Our study shows the significant effect on CPAP delivery and imposed work of breathing when using high-resistance interfaces and narrow expiratory tubing in bCPAP systems. New systems should include low-resistance interfaces and wide-bore tubing and be compared with the original bCPAP. Referring to all systems that bubble as bCPAP is misleading and potentially hazardous.