PT  - JOURNAL ARTICLE
AU  - Seilesh Kadambari
AU  - Elizabeth Whittaker
AU  - Hermione Lyall
TI  - Postnatally acquired cytomegalovirus infection in extremely premature infants: how best to manage?
AID  - 10.1136/archdischild-2019-317650
DP  - 2020 May 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - 334--339
VI  - 105
IP  - 3
4099  - http://fn.bmj.com/content/105/3/334.short
4100  - http://fn.bmj.com/content/105/3/334.full
SO  - Arch Dis Child Fetal Neonatal Ed2020 May 01; 105
AB  - Postnatal cytomegalovirus (pCMV) infection is a common viral infection typically occurring within the first months of life. pCMV refers to postnatal acquisition of CMV rather than postnatal manifestations of antenatal or perinatal acquired CMV. pCMV is usually asymptomatic in term infants, but can cause symptomatic disease in preterm (gestational age <32 weeks) and very low birth weight (<1500 g) infants resulting in sepsis, pneumonia, thrombocytopaenia, neutropaenia, hepatitis, colitis and occasionally death. There are significant uncertainties regarding the management of premature infants with pCMV disease which is in part due to our limited understanding of the natural history of this disease. This review describes the current epidemiology and clinical manifestations of pCMV disease which should alert clinicians to test for CMV and also outlines a strategy to manage the condition.