RT Journal Article SR Electronic T1 Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 225 OP 228 DO 10.1136/archdischild-2018-315711 VO 105 IS 2 A1 Ujwal Kariholu A1 Paolo Montaldo A1 Theodora Markati A1 Peter J Lally A1 Russell Pryce A1 Justinas Teiserskas A1 Natasha Liow A1 Vânia Oliveira A1 Aung Soe A1 Seetha Shankaran A1 Sudhin Thayyil YR 2020 UL http://fn.bmj.com/content/105/2/225.abstract AB Objectives To examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE).Data source MEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using ‘hypoxic ischaemic encephalopathy’, ‘newborn’ and ‘hypothermia’, and ‘clinical trials’ as medical subject headings and terms. Manual search of the reference lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles.Study selection Randomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care.Data extraction Safety and efficacy data extracted independently by two reviewers and analysed.Results We included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta-analysis. Adverse outcomes occurred in 11/56 (19.6%) of the cooled babies and 12/61 (19.7%) of the usual care babies (risk ratio 1.11 (95% CIs 0.55 to 2.25)).Conclusions Current evidence is insufficient to recommend routine therapeutic hypothermia for babies with mild encephalopathy and significant benefits or harm cannot be excluded.