TY - JOUR T1 - Physiological-based cord clamping in preterm infants using a new purpose-built resuscitation table: a feasibility study JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F396 LP - F402 DO - 10.1136/archdischild-2018-315483 VL - 104 IS - 4 AU - Emma Brouwer AU - Ronny Knol AU - Alex S N Vernooij AU - Thomas van den Akker AU - Patricia E Vlasman AU - Frans J C M Klumper AU - Philip DeKoninck AU - Graeme R Polglase AU - Stuart B Hooper AU - Arjan B te Pas Y1 - 2019/07/01 UR - http://fn.bmj.com/content/104/4/F396.abstract N2 - Objective Physiological-based cord clamping (PBCC) led to a more stable cardiovascular adaptation and better oxygenation in preterm lambs, but in preterm infants, this approach has been challenging. Our aim was to assess the feasibility of PBCC, including patterns of oxygen saturation (SpO2) and heart rate (HR) during stabilisation in preterm infants using a new purpose-built resuscitation table.Design Observational study.Setting Tertiary referral centre, Leiden University Medical Centre, The Netherlands.Patients Infants born below 35 weeks’ gestational age.Interventions Infants were stabilised on a new purpose-built resuscitation table (Concord), provided with standard equipment needed for stabilisation. Cord clamping was performed when the infant was stable (HR >100 bpm, spontaneous breathing on continuous positive airway pressure with tidal volumes >4 mL/kg, SpO2 ≥25th percentile and fraction of inspired oxygen (FiO2) <0.4).Results Thirty-seven preterm infants were included; mean (SD) gestational age of 30.9 (2.4) weeks, birth weight 1580 (519) g. PBCC was successful in 33 infants (89.2%) and resulted in median (IQR) cord clamping time of 4:23 (3:00–5:11) min after birth. There were no maternal or neonatal adverse events. In 26/37 infants, measurements were adequate for analysis. HR was 113 (81–143) and 144 (129–155) bpm at 1 min and 5 min after birth. SpO2 levels were 58%(49%–60%) and 91%(80%–96%)%), while median FiO2 given was 0.30 (0.30–0.31) and 0.31 (0.25–0.97), respectively.Conclusion PBCC in preterm infants using the Concord is feasible. HR remained stable, and SpO2 quickly increased with low levels of oxygen supply.Trial registration number NTR6095, results. ER -