TY - JOUR T1 - Evidence that therapeutic hypothermia should be continued for 72 hours JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F225 LP - F225 DO - 10.1136/archdischild-2018-315844 VL - 104 IS - 2 AU - Joanne O Davidson AU - Malcolm Battin AU - Alistair J Gunn Y1 - 2019/03/01 UR - http://fn.bmj.com/content/104/2/F225.1.abstract N2 - There is compelling clinical evidence that 72 hours of therapeutic hypothermia for infants with moderate to severe hypoxic ischaemic encephalopathy (HIE) significantly improves outcomes.1 Of concern, a recent Australian survey of clinical practice reported that hypothermia was stopped before 72 hours in 31% of infants who met the recommended entry criteria.2 Although in many cases this was for palliative care, in others it was for an ‘adverse event’ (34%) or clinical improvement (6%). Given the exceptional safety record of therapeutic hypothermia in multiple trials,1 it is unclear whether the apparent adverse events were related to hypothermia. Moreover, many infants were cooled who did not meet the criteria for cooling, for example, for mild HIE. Among the infants … ER -