RT Journal Article
SR Electronic
T1 Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F474
OP F478
DO 10.1136/archdischild-2017-313238
VO 103
IS 5
A1 Benjamin Cailes
A1 Christina Kortsalioudaki
A1 Jim Buttery
A1 Santosh Pattnayak
A1 Anne Greenough
A1 Jean Matthes
A1 Alison Bedford Russell
A1 Nigel Kennea
A1 Paul T Heath
A1 ,
YR 2018
UL http://fn.bmj.com/content/103/5/F474.abstract
AB Objective To define the susceptibilities of the common causative pathogens of neonatal sepsis in the UK.Design Retrospective analysis of the prospectively collected neonIN infection surveillance network data between 2005 and 2014.Setting 30 neonatal units in the UK.Patients Newborns admitted to participating neonatal units who return a positive blood, cerebrospinal fluid or urine culture and are treated with at least 5 days of appropriate antibiotics.Results 1568 isolates with recorded antimicrobial data were collected including 328 early-onset sepsis (EOS) isolates and 1240 late-onset sepsis (LOS) isolates. The majority of EOS pathogens (>92%) were susceptible to the four empirical commonly used antimicrobial combinations (eg, 93% for benzylpenicillin/gentamicin), while LOS pathogens demonstrated higher levels of resistance (eg, 89% for flucloxacillin/gentamicin). Among infants<1500 g and <32 weeks gestation, an amoxicillin/gentamicin combination demonstrated a trend towards improved coverage of EOS isolates than benzylpenicillin/gentamicin (93% vs 86%, p=0.211).Conclusions This analysis provides insights into the patterns of antimicrobial resistance among UK neonatal pathogens. These data will inform areas of future research and can be used to update national evidence-based guidelines on antimicrobial usage.