TY - JOUR T1 - Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F383 LP - F387 DO - 10.1136/archdischild-2017-313321 VL - 103 IS - 4 AU - Peter J Lally AU - Paolo Montaldo AU - Vânia Oliveira AU - Ravi Shankar Swamy AU - Aung Soe AU - Seetha Shankaran AU - Sudhin Thayyil Y1 - 2018/07/01 UR - http://fn.bmj.com/content/103/4/F383.abstract N2 - We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9 hours (IQR 5–13) due to rapid clinical improvement. Five (50%) had injury on MRI or spectroscopy, and two (20%) had an abnormal neurodevelopmental outcome at 2 years. Premature cessation of cooling therapy in babies with mild neonatal encephalopathy does not exclude residual brain injury and adverse long-term neurodevelopmental outcomes. This study refers to babies recruited into the MARBLE study (NCT01309711, pre-results stage). ER -