PT - JOURNAL ARTICLE AU - Peter J Lally AU - Paolo Montaldo AU - Vânia Oliveira AU - Ravi Shankar Swamy AU - Aung Soe AU - Seetha Shankaran AU - Sudhin Thayyil TI - Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy AID - 10.1136/archdischild-2017-313321 DP - 2018 Jul 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - F383--F387 VI - 103 IP - 4 4099 - http://fn.bmj.com/content/103/4/F383.short 4100 - http://fn.bmj.com/content/103/4/F383.full SO - Arch Dis Child Fetal Neonatal Ed2018 Jul 01; 103 AB - We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9 hours (IQR 5–13) due to rapid clinical improvement. Five (50%) had injury on MRI or spectroscopy, and two (20%) had an abnormal neurodevelopmental outcome at 2 years. Premature cessation of cooling therapy in babies with mild neonatal encephalopathy does not exclude residual brain injury and adverse long-term neurodevelopmental outcomes. This study refers to babies recruited into the MARBLE study (NCT01309711, pre-results stage).