PT - JOURNAL ARTICLE AU - Karen M Logan AU - Chris Gale AU - Matthew J Hyde AU - Shalini Santhakumaran AU - Neena Modi TI - Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis AID - 10.1136/archdischild-2015-309750 DP - 2017 Jan 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - F65--F72 VI - 102 IP - 1 4099 - http://fn.bmj.com/content/102/1/F65.short 4100 - http://fn.bmj.com/content/102/1/F65.full SO - Arch Dis Child Fetal Neonatal Ed2017 Jan 01; 102 AB - Objective Maternal glycaemia and anthropometry-derived newborn adiposity are strongly correlated. The children of mothers with diabetes are at greater risk of adverse metabolic health, and increased adiposity is a plausible mediator. We undertook a systematic review and meta-analysis to compare adiposity in infants of diabetic mothers (IDM) and infants of mothers without diabetes (NIDM).Design We identified observational studies reporting adiposity in IDM and NIDM. We searched references, traced forward citations and contacted authors for additional data. We considered all body composition techniques and compared fat mass, fat-free mass, body fat % and skinfold thickness. We used random effects meta-analyses and performed subgroup analyses by maternal diabetes type (type 1, type 2 and gestational) and infant sex. We examined the influence of pre-pregnancy body mass index (BMI) and conducted sensitivity analyses.Results We included data from 35 papers and over 24 000 infants. IDM have greater fat mass than NIDM (mean difference (95% CI)): 83 g (49 to 117). Fat mass is greater in infants of mothers with gestational diabetes: 62 g (29 to 94) and type 1 diabetes: 268 g (139 to 397). Insufficient studies reported data for type 2 diabetes separately. Compared with NIDM, fat mass was greater in IDM boys: 87 g (30 to 145), but not significantly different in IDM girls: 42 g (−33 to 116). There was no attenuation after adjustment for maternal BMI.Conclusions IDM have significantly greater adiposity in comparison with NIDM. These findings are justification for studies to determine whether measures to reduce infant adiposity will improve later health.