RT Journal Article SR Electronic T1 Neonatal EEG and neurodevelopmental outcome in preterm infants born before 32 weeks JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP F253 OP F259 DO 10.1136/archdischild-2015-308664 VO 101 IS 3 A1 Maximilien Périvier A1 Jean-Christophe Rozé A1 Géraldine Gascoin A1 Matthieu Hanf A1 Bernard Branger A1 Valérie Rouger A1 Isabelle Berlie A1 Yannis Montcho A1 Yann Péréon A1 Cyril Flamant A1 Sylvie Nguyen The Tich YR 2016 UL http://fn.bmj.com/content/101/3/F253.abstract AB Objective To assess the value of neonatal EEG for predicting non-optimal neurodevelopmental outcomes in very preterm infants, using a multimodal strategy of evaluation comprising brain imaging and clinical assessment.Design and setting Between 2003 and 2009, we performed an observational, population-based study. Out of 2040 eligible preterm infants born before 32 weeks, 1954 were enrolled in the French regional Loire Infant Follow-Up Team (LIFT) cohort. 1744 (89%) of these completed the follow-up. Neonatal EEGs were recorded prospectively as two EEGs during the first 2 weeks of life and then one every 2 weeks up to 33 weeks.Main outcome measures The neurodevelopmental outcome was assessed by physical examination, the Brunet–Lézine Test and/or the Age and Stages Questionnaire at 2 years of corrected age.Results Of the 1744 infants assessed at 2 years, 422 had a non-optimal outcome. A total of 4804 EEGs were performed, and 1345 infants had at least one EEG. EEG abnormalities were predictive of non-optimal outcomes after controlling for confounding factors such as severe intracranial lesions detected by brain imaging. Transient moderate and severe abnormalities were independent predictors of non-optimal outcomes with an OR and 95% CI of 1.49 (1.08 to 2.04) and 2.38 (1.49 to 3.81), respectively. In the validation group, the predictive risk stratification tree identified severe abnormalities as a factor contributing to the prognosis of two subgroups: infants with severe cranial lesions and infants with a normal examination at discharge and without severe cranial lesions.