TY - JOUR T1 - Effect of surgical ligation of the patent ductus arteriosus on cerebral perfusion of premature infants in the postoperative period JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F277 LP - F277 DO - 10.1136/archdischild-2015-309793 VL - 101 IS - 3 AU - A T MacLaren AU - A M Heuchan Y1 - 2016/05/01 UR - http://fn.bmj.com/content/101/3/F277.abstract N2 - Research into the effects of surgical ligation of the ductus arteriosus (DA) on regional tissue perfusion is limited. Near-infrared spectroscopy (NIRS) is a non-invasive technique for monitoring regional mixed arteriovenous saturations in capillary beds. Previous data suggest that DA closure may result in impaired cerebral perfusion1 because of alterations in pulmonary mechanics or cardiac function.2 These changes have been implicated in the aetiology of adverse neurodevelopmental outcome in neonates after DA ligation.3 In our neonatal unit, around 20 DA ligations are performed per year. Cerebral NIRS is routinely applied perioperatively using a non-adhesive positioning technique. … ER -