@article {WeiszF59, author = {Dany E Weisz and Sandesh Shivananda and Elizabeth Asztalos and Wendy Yee and Anne Synnes and Shoo K Lee and Prakesh S Shah}, editor = {Andrews, Wayne and Barrington, Keith and Bullied, Barbara and Canning, Rody and Alvaro, Ruben and Dow, Kimberly and Dunn, Michael and Harrison, Adele and James, Andrew and Kalapesi, Zarin and Kovacs, Lajos and da Silva, Orlando and McMillan, Douglas D. and Ojah, Cecil and Aziz, Abraham Peliowski/Khalid and Piedboeuf, Bruno and Riley, Patricia and Faucher, Daniel and Rouvinez-Bouali, Nicole and Sankaran, Koravangattu and Seshia, Mary and Cieslak, Zenon and Walti, Herve}, title = {Intrapartum magnesium sulfate and need for intensive delivery room resuscitation}, volume = {100}, number = {1}, pages = {F59--F65}, year = {2015}, doi = {10.1136/archdischild-2013-305884}, publisher = {BMJ Publishing Group}, abstract = {Objective To evaluate the association of intrapartum magnesium sulfate for fetal neuroprotection (MgSO4-FN) with the delivery room resuscitation and neonatal outcomes of preterm infants in an era of minimisation of invasive mechanical ventilation. Design Retrospective cohort study. Setting Neonatal intensive care units in the Canadian Neonatal Network. Patients and intervention Preterm infants (230 to 316 weeks gestational age) born in 2011 or 2012. Resuscitation requirements and neonatal outcomes were compared between infants exposed and unexposed to intrapartum MgSO4-FN. Main outcome measures The primary outcome was a composite outcome of {\textquoteleft}intensive resuscitation{\textquoteright}, defined as the need for intubation and ventilation or chest compressions or epinephrine administration in the delivery room. Secondary outcomes included mortality and major neonatal morbidities. Results Of 6015 eligible infants, 1387 (23.1\%) were exposed to intrapartum MgSO4-FN. Significantly fewer MgSO4-FN infants (41.0\% vs 44.6\%, p=0.02) required intensive resuscitation. However, after adjustment for confounders, this difference was no longer significant (adjusted OR (AOR) 0.88; 95\% CI 0.66 to 1.17). Infants exposed to MgSO4-FN had decreased odds of death (AOR 0.61; 95\% CI 0.40 to 0.94), but there was no difference in neonatal morbidities compared with the unexposed infants. Conclusions Intrapartum MgSO4 for fetal neuroprotection was not associated with an increased need for intensive delivery room resuscitation in this cohort of preterm infants.}, issn = {1359-2998}, URL = {https://fn.bmj.com/content/100/1/F59}, eprint = {https://fn.bmj.com/content/100/1/F59.full.pdf}, journal = {Archives of Disease in Childhood - Fetal and Neonatal Edition} }