RT Journal Article
SR Electronic
T1 Antenatal substance misuse and smoking and newborn hypoxic challenge response
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F143
OP F148
DO 10.1136/archdischild-2015-308491
VO 101
IS 2
A1 Kamal Ali
A1 Thomas Rossor
A1 Ravindra Bhat
A1 Kim Wolff
A1 Simon Hannam
A1 Gerrard F Rafferty
A1 Janet L Peacock
A1 Anne Greenough
YR 2016
UL http://fn.bmj.com/content/101/2/F143.abstract
AB Objectives Infants of smoking (S) and substance misusing (SM) mothers have an increased risk of sudden infant death syndrome. The aim of this study was to test the hypothesis that infants of SM or S mothers compared with infants of non-SM, non-smoking mothers (controls) would have a poorer ventilatory response to hypoxia, which was particularly marked in the SM infants.Design Physiological study.Setting Tertiary perinatal centre.Patients 21 SM; 21 S and 19 control infants. Infants were assessed before maternity/neonatal unit discharge.Interventions Maternal and infant urine samples were tested for cotinine, cannabinoids, opiates, amphetamines, methadone, cocaine and benzodiazepines.Main outcome measures During quiet sleep, the infants were switched from breathing room air to 15% oxygen and changes in minute volume were assessed.Results The SM infants had a greater mean increase (p=0.028, p=0.034, respectively) and a greater magnitude of decline (p<0.001, p=0.018, respectively) in minute volume than the S infants and the controls. The rate of decline in minute volume was greater in the SM infants (p=0.008) and the S infants (p=0.011) compared with the controls.Conclusions Antenatal substance misuse and smoking affect the infant's ventilatory response to a hypoxic challenge.