PT  - JOURNAL ARTICLE
AU  - Johnson, Samantha
AU  - Evans, T Alun
AU  - Draper, Elizabeth S
AU  - Field, David J
AU  - Manktelow, Bradley N
AU  - Marlow, Neil
AU  - Matthews, Ruth
AU  - Petrou, Stavros
AU  - Seaton, Sarah E
AU  - Smith, Lucy K
AU  - Boyle, Elaine M
TI  - Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study
AID  - 10.1136/archdischild-2014-307684
DP  - 2015 Jul 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F301--F308
VI  - 100
IP  - 4
4099  - http://fn.bmj.com/content/100/4/F301.short
4100  - http://fn.bmj.com/content/100/4/F301.full
SO  - Arch Dis Child Fetal Neonatal Ed2015 Jul 01; 100
AB  - Objective There is a paucity of data relating to neurodevelopmental outcomes in infants born late and moderately preterm (LMPT; 32+0–36+6 weeks). This paper present the results of a prospective, population-based study of 2-year outcomes following LMPT birth.Design 1130 LMPT and 1255 term-born children were recruited at birth. At 2 years corrected age, parents completed a questionnaire to assess neurosensory (vision, hearing, motor) impairments and the Parent Report of Children's Abilities-Revised to identify cognitive impairment. Relative risks for adverse outcomes were adjusted for sex, socio-economic status and small for gestational age, and weighted to account for over-sampling of term-born multiples. Risk factors for cognitive impairment were explored using multivariable analyses.Results Parents of 638 (57%) LMPT infants and 765 (62%) controls completed questionnaires. Among LMPT infants, 1.6% had neurosensory impairment compared with 0.3% of controls (RR 4.89, 95% CI 1.07 to 22.25). Cognitive impairments were the most common adverse outcome: LMPT 6.3%; controls 2.4% (RR 2.09, 95% CI 1.19 to 3.64). LMPT infants were at twice the risk for neurodevelopmental disability (RR 2.19, 95% CI 1.27 to 3.75). Independent risk factors for cognitive impairment in LMPT infants were male sex, socio-economic disadvantage, non-white ethnicity, preeclampsia and not receiving breast milk at discharge.Conclusions Compared with term-born peers, LMPT infants are at double the risk for neurodevelopmental disability at 2 years of age, with the majority of impairments observed in the cognitive domain. Male sex, socio-economic disadvantage and preeclampsia are independent predictors of low cognitive scores following LMPT birth.