TY - JOUR T1 - Growth restriction and gender influence cerebral oxygenation in preterm neonates JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F156 LP - F161 DO - 10.1136/archdischild-2015-308843 VL - 101 IS - 2 AU - Emily Cohen AU - Willem Baerts AU - Thomas Alderliesten AU - Jan Derks AU - Petra Lemmers AU - Frank van Bel Y1 - 2016/03/01 UR - http://fn.bmj.com/content/101/2/F156.abstract N2 - Objective To investigate the effect of fetal growth restriction and gender on cerebral oxygenation in preterm neonates during the first 3 days of life.Design Case–control study.Setting Neonatal Intensive Care Unit of the Wilhelmina Children's Hospital, The Netherlands.Patients 68 (41 males) small for gestational age (SGA) (birth weight <10th percentile) and 136 (82 males) appropriate for gestational age (AGA) (birth weight 20th–80th percentile) neonates, matched for gender, gestational age, ventilatory and blood pressure support.Methods Regional cerebral oxygen saturation (rScO2) and cerebral fractional tissue oxygen extraction (cFTOE) as measured by near-infrared spectroscopy throughout the first 72 h of life were compared between SGA and AGA neonates. The effect of gender was also explored within these comparisons.Results SGA neonates demonstrated higher rScO2 (71% SEM 0.2 vs 68% SEM 0.2) and lower cFTOE (0.25 SEM 0.002 vs 0.29 SEM 0.002) than AGA neonates. There was an independent effect of gender on rScO2 and cFTOE, resulting in the finding that SGA males displayed highest rScO2 and lowest cFTOE (73% SEM 0.3 respectively 0.24 SEM 0.003). AGA males and SGA females showed comparable rScO2 (69% SEM 0.2 vs 69% SEM 0.4) and cFTOE (0.28 SEM 0.002 vs 0.28 SEM 0.004). AGA females showed lowest rScO2 and highest cFTOE (66% SEM 0.2 respectively 0.30 SEM 0.002).Conclusions Growth restriction and gender influence cerebral oxygenation and oxygen extraction in preterm neonates throughout the first 3 days of life. ER -