PT - JOURNAL ARTICLE AU - Razaz, Neda AU - Boyce, W Thomas AU - Brownell, Marni AU - Jutte, Douglas AU - Tremlett, Helen AU - Marrie, Ruth Ann AU - Joseph, K S TI - Five-minute Apgar score as a marker for developmental vulnerability at 5 years of age AID - 10.1136/archdischild-2015-308458 DP - 2016 Mar 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - F114--F120 VI - 101 IP - 2 4099 - http://fn.bmj.com/content/101/2/F114.short 4100 - http://fn.bmj.com/content/101/2/F114.full SO - Arch Dis Child Fetal Neonatal Ed2016 Mar 01; 101 AB - Objective To assess the relationship between the 5 min Apgar score and developmental vulnerability at 5 years of age.Design Population-based retrospective cohort study.Setting Manitoba, Canada.Participants All children born between 1999 and 2006 at term gestation, with a documented 5 min Apgar score.Exposure 5 min Apgar score.Main outcome measures Childhood development at 5 years of age, expressed as vulnerability (absent vs present) on five domains of the Early Development Instrument: physical health, social competence, emotional maturity, language and cognitive development, and communication skills.Results Of the 33 883 children in the study, most (82%) had an Apgar score of 9; 1% of children had a score <7 and 5.6% had a score of 10. Children with Apgar scores <10 had higher odds of vulnerability on the physical domain at age 5 years compared with children with a score of 10 (eg, adjusted OR (aOR) for Apgar 9=1.23, 95% CI 1.05 to 1.44). Similarly, children with Apgar scores of <10 were more vulnerable on the emotional domain (eg, aOR for Apgar 9=1.20, 95% CI 1.03 to 1.41). Nevertheless, the Apgar-based prognostic model had a poor sensitivity for physical vulnerability (19%, 95% CI 18% to 20%). Although the Apgar score-based prognostic model had reasonable calibration ability and risk-stratification accuracy for identifying developmentally vulnerable children, classification accuracy was poor.Conclusions The risk of developmental vulnerability at 5 years of age is inversely associated with the 5 min Apgar score across its entire range, and the score can serve as a population-level indicator of developmental risk.