PT - JOURNAL ARTICLE AU - T Whitby AU - P McGowan AU - M A Turner AU - C Morgan TI - Concentrated parenteral nutrition solutions and central venous catheter complications in preterm infants AID - 10.1136/archdischild-2014-306409 DP - 2015 May 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - F250--F252 VI - 100 IP - 3 4099 - http://fn.bmj.com/content/100/3/F250.short 4100 - http://fn.bmj.com/content/100/3/F250.full SO - Arch Dis Child Fetal Neonatal Ed2015 May 01; 100 AB - Standardised, concentrated neonatal parenteral nutrition (PN) regimens can overcome early nutritional deficits in very preterm infants. A PN regimen with increased macronutrient content (standardised, concentrated, added macronutrients parenteral (SCAMP)) has been shown to improve early head growth in a randomised controlled trial. Line complications including late onset sepsis were secondary outcomes of this study. Infants were started on standardised, concentrated PN at birth and randomised at 2–5 days to either switch to SCAMP or remain on control PN. Central venous catheter (CVC), blood culture (BC) and inflammatory marker data were collected for the 28-day intervention period. 150 infants were randomised with mean (SD) birth weight (g) of 900 (158) versus 884 (183) in SCAMP (n=74) and control (n=76) groups, respectively. There were no differences in CVC use/type or duration or in positive/negative BC with/without associated C reactive protein rise in SCAMP versus control groups. Increasing the macronutrient content of a standardised, concentrated neonatal PN regimen does not increase CVC complication rates. Trial registration number ISRCTN 76597892.