TY - JOUR T1 - Change in practice after the Surfactant, Positive Pressure and Oxygenation Randomised Trial JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F386 LP - F390 DO - 10.1136/archdischild-2014-306057 VL - 99 IS - 5 AU - Jaclyn M LeVan AU - Luc P Brion AU - Lisa A Wrage AU - Marie G Gantz AU - Myra H Wyckoff AU - Pablo J Sánchez AU - Roy Heyne AU - Mambarambath Jaleel AU - Neil N Finer AU - Waldemar A Carlo AU - Abhik Das AU - Barbara J Stoll AU - Rosemary D Higgins Y1 - 2014/09/01 UR - http://fn.bmj.com/content/99/5/F386.abstract N2 - Objective To test the hypothesis that the proportion of endotracheal intubation (ETI) in the delivery room (DR) decreased in Neonatal Research Network (NRN) centres after the National Institute of Child Health and Human Development NRN Surfactant, Positive Pressure, and Oxygenation Randomised Trial (SUPPORT). Design Retrospective cohort study using the prospective NRN generic database. Setting Eleven centres that participated in the SUPPORT trial and remained part of the NRN. Preterm neonates 240/7–276/7 weeks’ gestational age enrolled in the SUPPORT trial were randomised to: (1) DR continuous positive airway pressure or DR ETI with early surfactant administration; and (2) oxygen saturation targets of 85–89% or 91–95%. The prior NRN feasibility trial had assessed the feasibility of randomisation to continuous positive airway pressure versus ETI. Patients Infants 240/7–276/7 weeks’ gestational age, excluding infants with syndromes or major malformations and those on comfort care only. Main outcome measure Proportion of DR ETI. Results The proportion of DR ETI decreased significantly in the group of infants from centres that had not participated in the feasibility trial (91% before vs 75% after SUPPORT, adjusted relative risk 0.86, 95% CI 0.83–0.89, p<0.0001) but not in the group of infants from the other centres, where the proportion of ETI was already lower prior to initiation of the SUPPORT trial (61% before vs 58% after SUPPORT, adjusted relative risk 0.96, 95% CI 0.89 to 1.05, p=0.40). Conclusion This study shows that DR ETI changed after SUPPORT only in NRN centres that had not participated in a similar trial. Trial registration number NCT00063063 (GDB) and NCT00233324 (SUPPORT). ER -