TY - JOUR T1 - Sildenafil in bronchopulmonary dysplasia: safe to use? JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F369 LP - F369 DO - 10.1136/archdischild-2015-308164 VL - 100 IS - 4 AU - Andrew James Wardle AU - Georgia May Connolly AU - Tom Stonier AU - Robert Tulloh Y1 - 2015/07/01 UR - http://fn.bmj.com/content/100/4/F369.2.abstract N2 - One-third of preterm infants are diagnosed with bronchopulmonary dysplasia (BPD), a complex multifactorial disorder associated with significant morbidity. Associated pathologies include pulmonary hypertension (PH), a critical cardiorespiratory pathology with 48% 2-year mortality that affects up to a third of infants with BPD.1 Pulmonary vasodilatation in PH prolongs life, and phosphodiesterase-V inhibition is the primary approach for this.2 That stated, current evidence is limited to 45 patients across five case series.3 They demonstrate a reduction in overall mortality to 18%, but reservations remain regarding safety and efficacy.We therefore conducted a retrospective investigation into patients with BPD–PH managed at our centre between August 2008 and July … ER -