TY - JOUR T1 - Prenatal diagnosis of chromosomal imbalances JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F338 LP - F341 DO - 10.1136/archdischild-2013-304835 VL - 99 IS - 4 AU - Diana G Wellesley AU - Anneke Lucassen Y1 - 2014/07/01 UR - http://fn.bmj.com/content/99/4/F338.abstract N2 - Prenatal array comparative genome hybridisation (aCGH) testing has by and large replaced routine karyotyping in many healthcare settings. While this will lead to more diagnoses, uncertain, unexpected or unhelpful findings are also likely to increase. This is the case for aCGH in any setting, but we discuss the particular challenges the prenatal setting generates and suggest areas that need further debate and discussion as well as some pragmatic ways forward. ER -