RT Journal Article
SR Electronic
T1 PM.62 Five Year Retrospective Review of Antenatal Lamivudine (LAM) to Reduce the Perinatal Transmission of Hepatitis B (HBV)
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP A42
OP A43
DO 10.1136/archdischild-2013-303966.144
VO 98
IS Suppl 1
A1 AA Ali
A1 KG Glennon
A1 BK Kelleher
A1 ME Eogan
A1 VJ Jackson
A1 MB Brennan
A1 ML Lawless
A1 WF Ferguson
A1 JL Lambert
YR 2013
UL http://fn.bmj.com/content/98/Suppl_1/A42.4.abstract
AB Objectives To review the safety and efficacy of LAM in reducing the perinatal transmission of HBV. Methods Medical charts of HBV positive women who received treatment with LAM and who booked for antenatal care between 2007 and 2012 were retrospectively reviewed. Results Between 2007 – 2012, 34 pregnant HBV positive women received treatment with LAM during the third trimester. All were HbeAg positive, and 6/34 were anti-HbCore IgM positive, indicative of acute infection. Where tested, the predominant genotypes were B and C, occurring in 16/32 and 11/32 respectively. Genotype D was noted in 4/32 women. One woman was co-infected with Hepatitis C. Mean viral load (VL) pre-treatment was >1 × 108 IU/ml, mean VL closest to delivery was 6.5 × 106 IU/ml (P < 0.001). No resistance to LAM was identified in the 70% who were tested post treatment. Median delivery gestation was 39 weeks (range 37–41 weeks); 17/33 had a normal vaginal delivery, 5/33 had an instrumental delivery, 9/33 had a C section, 2 delivered elsewhere and one patient is still pregnant. Median birth weight was 3.49 kg (range 2.33–4.72 kg). All babies received HBV IgG and the first dose of vaccine within the first 24 hours of life. Of 33 live born infants, 17 were not infected, 8 left the country prior to the 8-month serology test, 6 have serology pending (not yet 8 months) and 2 were lost to follow up. Conclusions Treatment with LAM is a safe and effective. No vertical transmission of HBV was noted, and no adverse maternal or fetal effects were reported.