PT  - JOURNAL ARTICLE
AU  - Richard I King
AU  - Richard J Mackay
AU  - Christopher M Florkowski
AU  - Adrienne M Lynn
TI  - Electrolytes in sick neonates – which sodium is the right answer?
AID  - 10.1136/archdischild-2011-300929
DP  - 2013 Jan 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F74--F76
VI  - 98
IP  - 1
4099  - http://fn.bmj.com/content/98/1/F74.short
4100  - http://fn.bmj.com/content/98/1/F74.full
SO  - Arch Dis Child Fetal Neonatal Ed2013 Jan 01; 98
AB  - Introduction Hypoproteinaemia leads to spuriously high-sodium values when measured by indirect ion-selective electrodes (ISE) as used in main laboratory analysers compared with direct ISE employed in point-of-care analysers (POCT). The authors, therefore, investigated the occurrence of hypoalbuminaemia and its effect on measured sodium from POCT and the main laboratory analyser of neonatal intensive-care samples. Method Sodium, in paired retrospective samples, measured by the main laboratory and neonatal unit blood-gas (POCT) analysers were compared. Results Hypoalbuminaemia (<30 g/l) was present in 1400/2420 paired results. Sodium was higher when measured by laboratory analyser, the difference increased with decreasing albumin; sodium (laboratory – POCT)=7.6 (±1.1)–0.22 (±0.04)×albumin. A difference >3 mmol/l was present in 31% and consequently underestimated (9.4%) hyponatraemia and overestimated (3.8%) hypernatraemia. Conclusion Hypoalbuminaemia is common in sick neonates and monitoring electrolytes using POCT and laboratory analysers frequently yield significantly different results with consequent misclassification. In these patients, measurement of electrolytes by direct ISE (blood-gas analyser) may be more accurate.