@article {RussellA14, author = {H Russell and E Moore and E Bayman and S Cooper and K Tallur and E Murdoch}, title = {PF.36 Audit of Congenital Central Nervous System (CNS) Anomalies: Patterns of Referrals and Service Implications After the Introduction of First Trimester Screening and Second Trimester Anomaly Ultrasound in South East Scotland}, volume = {98}, number = {Suppl 1}, pages = {A14--A14}, year = {2013}, doi = {10.1136/archdischild-2013-303966.047}, publisher = {BMJ Publishing Group}, abstract = {67 cases of fetal CNS anomalies from January 2010 {\textendash} December 2011 were retrospectively reviewed. 80.6\% from within the tertiary unit, and 19.4\% referred from district general hospitals. View this table:Abstract PF.36 Table Further investigations included chromosomal diagnosis; 1 CVS (normal), 7 amniocentesis (5 abnormal), 7 declined. Serology showed 3 positive for cytomegalovirus IgM. Fetal MRI was performed in 19 cases (28.4\%) at average gestation 25+3. A second MRI in 2 cases (2.9\%) at average gestation of 31+6. MRI was declined in 4 cases (5.9\%). MRI confirmed the diagnosis or added additional information in 84.2\%. Pregnancy outcomes were 23 livebirths, 43 terminations (5 fetocide) and 2 neonatal deaths. Post-mortem was performed in 55.2\% of cases (86.1\% of terminations). The findings added information in 40\% of cases, including 4 further chromosomal abnormalities. Of the livebirths, 43.4\% of babies were admitted to the Neonatal ICU with an average hospital admission of 21 days. Postnatal USS was performed in 82.6\% and MRI in 52.2\%. 82.6\% had outpatient follow-up: 21.7\% had a normal outcome, 21.7\% showed global or isolated motor delay, and 13.1\% were deceased. All were too early for a formal Baileys 2 year outcome. The management of congenital CNS anomalies requires significant multidisciplinary care, sequential USS and often additional MRI. This audit had added information which can inform the care pathway.}, issn = {1359-2998}, URL = {https://fn.bmj.com/content/98/Suppl_1/A14.2}, eprint = {https://fn.bmj.com/content/98/Suppl_1/A14.2.full.pdf}, journal = {Archives of Disease in Childhood - Fetal and Neonatal Edition} }