TY - JOUR T1 - PPO.30 Assessment of adverse perinatal outcomes in women with isolated PAPP-A <0.3 at firt trimester screening JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - A160 LP - A160 DO - 10.1136/archdischild-2014-306576.470 VL - 99 IS - Suppl 1 AU - K Skorupskaite AU - L Stirrat AU - N Palaniappan AU - C Shearing AU - S Cowan Y1 - 2014/06/01 UR - http://fn.bmj.com/content/99/Suppl_1/A160.1.abstract N2 - Background Maternal serum pregnancy-associated-plasma-protein-A (PAPP-A) was introduced as a part of combined first trimester trisomy 21 screening (nuchal translucency, PAPP-A and human chorionic gonadotropin) in 2011. We aimed to investigate whether isolated low PAPP-A (< 0.3MoM) was associated with stillbirth, preterm delivery and low birthweight in women booked for delivery in NHS Lothian in 2011. Methods We retrospectively reviewed case records of women with low PAPP-A level during 2011 (n = 154). Rate of stillbirth, preterm delivery and low birthweight were compared with a control group (n = 9603) who had a normal PAPP-A result, or had opted out of screening. Chi-squared test was used for comparison of rates. Statistical significance was considered at p < 0.05. Results Rates of stillbirth, preterm delivery and low birthweight were significantly higher in women with low PAPP-A (Table 1). View this table:Abstract PPO.30 Table 1 Conclusions Our results suggest that low PAPP-A at first trimester screening is associated with significantly higher rates of stillbirth, preterm delivery and low birthweight. ER -