RT Journal Article SR Electronic T1 Epidemiology of small intestinal atresia in Europe: a register-based study JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP F353 OP F358 DO 10.1136/fetalneonatal-2011-300631 VO 97 IS 5 A1 Kate E Best A1 Peter W G Tennant A1 Marie-Claude Addor A1 Fabrizio Bianchi A1 Patricia Boyd A1 Elisa Calzolari A1 Carlos Matias Dias A1 Berenice Doray A1 Elizabeth Draper A1 Ester Garne A1 Miriam Gatt A1 Ruth Greenlees A1 Martin Haeusler A1 Babak Khoshnood A1 Bob McDonnell A1 Carmel Mullaney A1 Vera Nelen A1 Hanitra Randrianaivo A1 Anke Rissmann A1 Joaquin Salvador A1 David Tucker A1 Diana Wellesly A1 Judith Rankin YR 2012 UL http://fn.bmj.com/content/97/5/F353.abstract AB Background The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. Methods Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. Results In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8). Conclusion This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.