TY - JOUR T1 - Neonatal stroke JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F377 LP - F384 DO - 10.1136/fetalneonatal-2010-196451 VL - 97 IS - 5 AU - M A Rutherford AU - L A Ramenghi AU - F M Cowan Y1 - 2012/09/01 UR - http://fn.bmj.com/content/97/5/F377.abstract N2 - Neonatal stroke encompasses a range of focal and multifocal ischaemic and haemorrhagic tissue injuries. This review will concentrate on focal brain injury that occurs as a consequence of arterial infarction, most frequently the left middle cerebral artery, or more rarely as a consequence of cerebral sinus venous thrombosis (CSVT). Both conditions are multifactorial in origin. The incidence of both acquired and genetic thrombophilic disorders in both mothers and infants is high although rarely causal in isolation. Neurodevelopmental morbidity occurs in over 50% of children. Specific therapy in the form of anticoagulation is currently only recommended in CSVT and needs to be carefully monitored in the presence of haemorrhage. ER -