RT Journal Article
SR Electronic
T1 Increased time to pregnancy is associated with suboptimal neurological condition of 2-year-olds
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F434
OP F436
DO 10.1136/archdischild-2012-303366
VO 98
IS 5
A1 Jorien Seggers
A1 Pamela Schendelaar
A1 Arend F Bos
A1 Maas Jan Heineman
A1 Karin J Middelburg
A1 Maaike L Haadsma
A1 Mijna Hadders-Algra
YR 2013
UL http://fn.bmj.com/content/98/5/F434.abstract
AB Objective To evaluate whether time to pregnancy (TTP) is associated with neurological condition of 2-year-old children born to subfertile parents. Design Data collected in a prospective, assessor-blinded follow-up study were used for cross-sectional analyses. Patients Participants were the singletons of the Groningen assisted reproductive technique cohort study: all children were born to subfertile couples (n=209). The active waiting TTP of the couples obtained from fertility charts was recorded in years and months, and was converted to decimal years. Main outcome measure The presence of minor neurological dysfunction (MND), assessed with the Hempel examination. Results MND was present in 16 (7.7%) children. TTP of children with MND (median 4.1, range 1.6–13.2) was significantly longer than that of children without MND (median 2.8, range 0.1–13.3; Mann-Whitney U test p=0.014). Logistic regression analysis on the contribution of TTP to MND resulted in a crude OR of 1.27 (95% CI 1.06 to 1.54). After correction for gestational age, parental age and parental level of education, the association remained statistically significant: OR=1.30 (95% CI 1.05 to 1.61). Conclusions Increased TTP was associated with suboptimal neurological development in 2-year-old children. This suggests that subfertility and its determinants are involved in the genesis of neurodevelopmental problems.