RT Journal Article
SR Electronic
T1 Does pulmonary function change during whole-body deep hypothermia?
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F374
OP F377
DO 10.1136/adc.2009.181826
VO 96
IS 5
A1 Cavallaro, Giacomo
A1 Filippi, Luca
A1 Cristofori, Gloria
A1 Colnaghi, Mariarosa
A1 Ramenghi, Luca
A1 Agazzani, Elisa
A1 Ronchi, Andrea
A1 Fiorini, Patrizio
A1 Mosca, Fabio
YR 2011
UL http://fn.bmj.com/content/96/5/F374.abstract
AB Whole-body deep hypothermia (DH) could be a new therapeutic strategy for asphyxiated newborn. Aim of this study was to describe how DH (core temperature 30–33°C) modifies the respiratory function if compared with mild hypothermia (MH; core temperature 33–34°C). This is an observational study. Results were obtained from a pilot study of safety of DH and topiramate in neonatal hypoxic-ischaemic encephalopathy. Fifty-seven newborns were enrolled: 29 patients in DH and 28 in MH. Recruitment criteria were moderate-severe hypoxic-ischaemic encephalopathy and gestational age ≥36 weeks. Mechanical ventilation was set to maintain SaO2 between 92% and 95%. Nineteen patients in DH and 18 in MH required mechanical ventilation. Of these patients, 10 and 12, respectively, did not required oxygen. No significant differences were observed in hours of oxygen and ventilation support, respiratory rate and PaCO2. Maximum FiO2, peak inspiratory pressure, positive end-expiratory pressure, minute ventilation and tidal volume during hypothermia were similar. Pulmonary function with different levels of hypothermia was similar.