TY - JOUR T1 - Efficacy and safety of intravenous Ig and alterations in haematological parameters of infants with isoimmune haemolytic disease JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F76 LP - F77 DO - 10.1136/archdischild-2011-300446 VL - 97 IS - 1 AU - B Freyne AU - F M O'Hare AU - E J Molloy Y1 - 2012/01/01 UR - http://fn.bmj.com/content/97/1/F76.2.abstract N2 - Intravenous Ig (IVIg – polyclonal Ig) administration to neonates with Rhesus-mediated isoimmune haemolytic disease has been shown to decrease the need for exchange transfusion (number needed to treat=2.7).1 The use of IVIg as an adjuvant treatment for neonatal sepsis has been extensively studied. A 2010 Cochrane systematic review of this application in preterm (<37 weeks)/low birthweight (<2500 g) infants analysed the results of 19 studies involving 5000 infants. The authors concluded that IVIg administration resulted in a 3–4% reduction in sepsis or serious infection but was not associated with decreased … ER -