TY - JOUR T1 - Linezolid for treatment of catheter-related cerebrospinal fluid infections in preterm infants JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F397 LP - F397 DO - 10.1136/adc.2008.140038 VL - 93 IS - 5 AU - M Langgartner AU - A Mutenthaler AU - N Haiden AU - A Pollak AU - A Berger Y1 - 2008/09/01 UR - http://fn.bmj.com/content/93/5/F397.1.abstract N2 - Ventriculostomy-related cerebrospinal fluid (CSF) infection remains a major problem in neonatal intensive care. The spectrum of pathogens causing these infections is dominated by coagulase-negative staphylococci, and vancomycin is the antibiotic of choice for treatment. However, vancomycin is known to have only poor penetration into the CSF when applied intravenously and is therefore being applied intraventricularly.1The oxazolidinone linezolid has antibacterial activity against most drug-resistant Gram-positive bacteria and has been shown to have excellent penetration into the CSF in adults.2 Trials on the pharmacokinetics and … ER -