PT  - JOURNAL ARTICLE
AU  - D V Joseph
AU  - J A Jackson
AU  - J Westaway
AU  - N A Taub
AU  - S A Petersen
AU  - M P Wailoo
TI  - Effect of parental smoking on cotinine levels in newborns
AID  - 10.1136/adc.2006.108506
DP  - 2007 Nov 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - F484--F488
VI  - 92
IP  - 6
4099  - http://fn.bmj.com/content/92/6/F484.short
4100  - http://fn.bmj.com/content/92/6/F484.full
SO  - Arch Dis Child Fetal Neonatal Ed2007 Nov 01; 92
AB  - Background: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful.Aim: To assess cotinine levels in infants of smoking parents.Method: Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development.Results: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% CI 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors.Conclusion: Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.