TY - JOUR T1 - The role of androgens in fetal growth: observational study in two genetic models of disordered androgen signalling JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F435 LP - F438 DO - 10.1136/adc.2009.173575 VL - 95 IS - 6 AU - Harriet L Miles AU - Sebastian Gidlöf AU - Anna Nordenström AU - Ken K Ong AU - Ieuan A Hughes Y1 - 2010/11/01 UR - http://fn.bmj.com/content/95/6/F435.abstract N2 - Objective To examine the role of androgens on birth weight in genetic models of altered androgen signalling. Setting Cambridge Disorders of Sex Development (DSD) database and the Swedish national screening programme for congenital adrenal hyperplasia (CAH). Patients (1) 29 girls with XY karyotype and mutation positive complete androgen insensitivity syndrome (CAIS); (2) 43 girls and 30 boys with genotype confirmed CAH. Main outcome measures Birth weight, birth weight-for-gestational-age (birth weight standard deviation score (SDS)) calculated by comparison with national references. Results Mean birth weight SDS in CAIS XY infants was higher than the reference for girls (mean, 95% CI: 0.4, 0.1 to 0.7; p=0.02) and was similar to the national reference for boys (0.1, −0.2 to 0.4). Birth weight SDS in CAH girls was similar to the national reference for girls (0.0, −0.2 to 0.2) and did not vary by severity of gene mutation. Birth weight SDS in CAH boys was also similar to the national reference for boys (0.2, −0.2 to 0.6). Conclusion CAIS XY infants have a birth weight distribution similar to normal male infants and birth weight is not increased in infants with CAH. Alterations in androgen signalling have little impact on birth weight. Sex dimorphism in birth size is unrelated to prenatal androgen exposure. ER -