%0 Journal Article %A B Caravale %A C Tozzi %A G Albino %A S Vicari %T Cognitive development in low risk preterm infants at 3–4 years of life %D 2005 %R 10.1136/adc.2004.070284 %J Archives of Disease in Childhood - Fetal and Neonatal Edition %P F474-F479 %V 90 %N 6 %X Background: Major neurological handicaps and neuropsychological disturbances are more common in ex-preterm children than their counterparts born at term. Objective: To establish in a prospective study whether a characteristic neuropsychological profile exists in ex-preterm children who do not exhibit neurodevelopmental deficits on routine clinical examination. Methods: Thirty intellectually normal children born preterm (30–34 weeks gestation) without major neurological disabilities and a control group of term children matched for age, sex, and parental educational and occupational status were assessed at 3–4 years of age to obtain a complete neuropsychological profile. Intellectual ability, language comprehension and expression, perceptual and visual motor function, working memory, and attention and behavioural problems were investigated. Results: Even in the absence of major neurological signs, children born preterm achieved lower mean scores than controls on the Stanford-Binet intelligence scale (110.8 v 121, p<0.001), visual perception test (33.8 v 42.7, p<0.001), visual motor integration test (42.6 v 47.4, p  =  0.049), memory for location test (8.4 v 9.5, p  =  0.007), sustained attention test (41.6 v 51.5, p  =  0.009), and the picture vocabulary test (33.3 v 44.7, p  =  0.021). Conclusions: Neuropsychological abnormalities can be detected early in childhood in apparently normal ex-preterm children and are consistent with a growing body of evidence that prematurity may be associated with long term neuropsychological morbidity in childhood and adolescence. %U https://fn.bmj.com/content/fetalneonatal/90/6/F474.full.pdf