TY - JOUR T1 - Congenital leukaemia after heavy abuse of permethrin during pregnancy JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F436 LP - F437 DO - 10.1136/fn.88.5.F436 VL - 88 IS - 5 AU - A Borkhardt AU - M Wilda AU - U Fuchs AU - L Gortner AU - I Reiss Y1 - 2003/09/01 UR - http://fn.bmj.com/content/88/5/F436.abstract N2 - A single case is described of congenital leukaemia with 11q23/MLL rearrangement in a preterm female newborn. Because of arachnophobia, the mother had heavily abused aerosolised permethrin, a widely used household insecticide. Permethrin is considered comparatively safe, but, in view of the mother’s history, its potential to induce cleavage of the MLL gene in cell culture was tested. Incubation of the BV173 cell line with 50 μM permethrin readily induced MLL cleavage. ER -