RT Journal Article
SR Electronic
T1 Congenital leukaemia after heavy abuse of permethrin during pregnancy
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F436
OP F437
DO 10.1136/fn.88.5.F436
VO 88
IS 5
A1 A Borkhardt
A1 M Wilda
A1 U Fuchs
A1 L Gortner
A1 I Reiss
YR 2003
UL http://fn.bmj.com/content/88/5/F436.abstract
AB A single case is described of congenital leukaemia with 11q23/MLL rearrangement in a preterm female newborn. Because of arachnophobia, the mother had heavily abused aerosolised permethrin, a widely used household insecticide. Permethrin is considered comparatively safe, but, in view of the mother’s history, its potential to induce cleavage of the MLL gene in cell culture was tested. Incubation of the BV173 cell line with 50 μM permethrin readily induced MLL cleavage.