TY - JOUR T1 - Suppressive effects of breast milk on oxidative DNA damage in very low birthweight infants JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F136 LP - F138 DO - 10.1136/adc.2002.018390 VL - 89 IS - 2 AU - H Shoji AU - T Shimizu AU - K Shinohara AU - S Oguchi AU - S Shiga AU - Y Yamashiro Y1 - 2004/03/01 UR - http://fn.bmj.com/content/89/2/F136.abstract N2 - Background: Human milk contains many kinds of antioxidant and is considered to prevent diseases mediated by oxygen free radicals in very low birthweight (VLBW) infants. Aims: To examine the antioxidant effects of breast milk in VLBW infants by determining urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, which is known to be a non-invasive marker for in vivo oxidative DNA damage. Methods: Urinary 8-OHdG concentrations were measured in 15 breast fed and 14 formula fed VLBW infants at 2, 7, 14, and 28 days of age. Results: Urinary 8-OHdG excretion at 14 and 28 days of age was significantly lower than at 2 and 7 days of age in the breast fed group, and significantly lower than in the formula fed group. Conclusion: This is the first direct evidence of the antioxidant action of human milk in VLBW infants. ER -