TY - JOUR T1 - Low soluble FcRIII receptor demonstrates reduced neutrophil reserves in preterm neonates JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - F160 LP - F160 DO - 10.1136/fn.83.2.F160 VL - 83 IS - 2 AU - ROBERT CARR AU - TOM W J HUIZINGA Y1 - 2000/09/01 UR - http://fn.bmj.com/content/83/2/F160.1.abstract N2 - Editor—Studies of human neonate granulopoiesis have been hampered by the lack of a marker of overall neutrophil cell mass. Assumptions about neonate granulopoiesis have therefore largely been extrapolated from rat data. Direct measurement of total neutrophil cell mass (in terms of neutrophils per g body weight) in newborn rats has shown that they have about one quarter the neutrophil mass of adult animals and that their neutrophil mass increases to adult levels by the time they are 4 weeks old.1 In addition, newborn rodents do not have the reserve pool of quiescent granulocyte progenitors, as found in adults, to recruit into production during sepsis. Circumstantial evidence for a similar immaturity of neutrophil production … ER -