RT Journal Article
SR Electronic
T1 Effects of vitamin E supplementation during erythropoietin treatment of the anaemia of prematurity
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP F324
OP F328
DO 10.1136/fn.88.4.F324
VO 88
IS 4
A1 A Pathak
A1 P Roth
A1 J Piscitelli
A1 L Johnson
YR 2003
UL http://fn.bmj.com/content/88/4/F324.abstract
AB Aims: To evaluate the effects of vitamin E supplementation on haemoglobin concentration and the requirement for transfusion in premature infants treated with erythropoietin and iron. Methods: Randomised, double blind, placebo controlled trial. Thirty infants ≤32 weeks gestation and ≤1250 g birth weight, who were defined as stable based on minimal requirements for respiratory support and phlebotomy, and absence of major congenital anomalies were enrolled. All were treated with erythropoietin and iron, and were randomised to receive, in addition, either vitamin E 50 IU/day or placebo for eight weeks or until discharge, whichever came first. Results: Despite higher vitamin E (α-tocopherol) levels in the experimental group in weeks 3 (49.0 v 28.1 μmol/l) and 8 (66.2 v 38.5 μmol/l), there were no differences in haemoglobin, reticulocyte count, iron concentration, or transfusion requirement. Conclusions: Oral vitamin E supplementation at 50 IU/day does not increase the response of preterm infants to erythropoietin and iron. Vitamin E obtained through standard nutrition may have been sufficient or higher doses may be required.